Receptor-mediated gonadotropin action in the ovary. Action of cytoskeletal element-disrupting agents on gonadotropin-induced steroidogenesis in rat luteal cells
نویسندگان
چکیده
منابع مشابه
Receptor-mediated gonadotropin action in the ovary. Demonstration of acute dependence of rat luteal cells on exogenously supplied steroid precursor (sterols) for gonadotropin-induced steroidogenesis.
Incubation of luteal cells with human, horse and rat sera, but not bovine sera resulted in enhanced basal and hCG-stimulated progesterone accumulation. The stimulatory effect of human or rat sera on basal, hCG- or 8 Br-cyclic AMP-induced progesterone synthesis in luteal cells was evident within 15-30 min after incubation, reaching a maximum after 3-4 h. The stimulatory effects of hCG and/or ser...
متن کاملReceptor-Mediated Gonadotropin Action in Ovary
The effect of gangliosides and cholera enterotoxin on 1251 choriogonadotropin binding, cAMP formation, protein kinase activation and progesterone production have been studied in isolated rat ovarian interstitial cells. A close correlation was observed between the amount of adenosine 3' : 5'monophosphate (CAMP) produced in the cells and the extent of the activation of protein kinase in response ...
متن کاملReceptor mediated gonadotropin action in gonadal tissues: relationship between blood cholesterol levels and gonadotropin stimulated steroidogenesis in isolated rat Leydig and luteal cells.
The present studies were performed to evaluate the role of steroid precursors and plasma lipoproteins in gonadal tissue steroidogenesis. Leydig cell suspension isolated from rat testes responded to hCG. Bt2cAMP, 8 Br-cAMP and cholera toxin with an increase in testosterone response. Administration of 4-aminopyrazolo[3,4-d]pyrimidine (4-APP) reduced the plasma cholesterol and testosterone levels ...
متن کاملeffect of lithium chloride on the luteal steroidogenesis in gonadotropin-stimulated rat
background: objective: this study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats. materials and methods: immature 23 days old wistar rats were divided into 10 groups; each group comprised of 8 rats, and induced with single injection of pregnant mare’s serum gonadotrophin (pmsg) and followed by...
متن کاملEffect of lithium chloride on the luteal steroidogenesis in gonadotropin-stimulated rat
BACKGROUND Main function of corpus luteum is progesterone synthesis that is significantly accompanied with an increase in levels of mRNA encoding of steroidogenic enzymes known as luteal markers. OBJECTIVE This study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats. MATERIALS AND METHODS Immatur...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1981
ISSN: 0264-6021
DOI: 10.1042/bj1940019